IMHO the most important factor is being able to read your opponents strategy. Most decks have answers to common win conditions, but knowing what cards in your hand you can resource and which you need to keep as future answers is key. Most games come down to a key turn where one player doesn't have an answer to his opponents plays and from there is spirals down hill fast.
Resourcing the wrong card is often the difference between a win and loss. That and playing a deck your opponent finds it hard to predict in turn.
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