Assuming you build minimum size decks, card advantage is the biggest determining factor in winning and losing in shadow era. That's why all my decks are built "to go second" meaning the most health and highest ability to retake the board.
How to create card advantage where there is none:
Let's take
Gravebone for example. It's turn 4. You went second. Your opponent has played the dreaded
Jasmine+
Aldon combo and the board is clear. Lightning strike won't help. Nova is a turn away and would really put you in a health hole PLUS they would still get the turn to do whatever they wanted. If they dropped a high health ally T5, you're likely still screwed.
A chimera would be crippled. Anything else would just get ran over. Playing a portal, rather than playing an ally, is a good idea. Playing a bella will just be a speed bump.
Portal in itself is -1 card advantage though, which is bad. You sacrifice a turn and set yourself up for it to be destroyed. If it sticks, you can send in a belladonna for a immediate card draw and death of his jasmine. This brings your card advantage back even. Now he will likely kill your Bella with his
Aldon or hero ability, but you still will have haste for one more turn plus an extra card.
Cards like
Portal and
Evil Ascendant don't have direct card advantage, but when applied correctly, aid greatly in the direction you built your deck. This is synergy ladies, and this is the second biggest determining factor in good deck building.
Evil Ascendant combined with infernal gargoyle is extreme synergy. Cards like sacrificial lamb on a hasted Bella on t6 is extreme synergy. You know she won't survive and you in turn get maximum reward for your play. 4 damage and 4 cards drawn for 2 cards played.
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