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The first gene identified was ryr1 patient with mild nemaline myopathy and mutation in acta1 showed core-like structures, too, in the muscle biopsy third locus for rod-core disease has been linked to region of chromosome 15 but the precise gene has not yet been identified section 3b: muscle disease specific diseases minicores along with nemaline bodies were seen in the patients with cofilin mutation zebra body myopathy zebra bodies, which consist of alternating stripes of electron- dense and electron-lucent z-disk and i-band material were seen in three of seven patients with nemaline myopathy caused by absence of skeletal muscle actin it is possible therefore that patients diagnosed with zebra-body myopathy also lack actin, but this remains to be proved.
The significance of excessive autophagy in the pathogenesis of pompe and danon disease and xmea has recently been reviewed accumulation of autophagic vacuoles is also feature of other myopathies such as distal myopathy with rimmed vacuoles and inclusion body myopathies, which are allelic disorders, and chloroquine-induced myopathy mutations in the gene encoding for chaperone involved in chaperone-mediated macroautophagy of misfolded proteins have been identified in form of distal hereditary motor neuropathy lamp- danon disease is characterized by combination of cardiomyopathy, myopathy, and mental retardation.
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